Journal article
A Metal–Phenolic Network-Enabled Nanoadjuvant to Modulate Immune Responses
Z Wang, C Cortez-Jugo, Y Yang, J Chen, T Wang, R De Rose, J Cui, F Caruso
Small | WILEY-V C H VERLAG GMBH | Published : 2024
Abstract
The presence of hierarchical suppressive pathways in the immune system combined with poor delivery efficiencies of adjuvants and antigens to antigen-presenting cells are major challenges in developing advanced vaccines. The present study reports a nanoadjuvant constructed using aluminosilicate nanoparticles (as particle templates), incorporating cytosine–phosphate–guanosine (CpG) oligonucleotides and small-interfering RNA (siRNA) to counteract immune suppression in antigen-presenting cells. Furthermore, the application of a metal–phenolic network (MPN) coating, which can endow the nanoparticles with protective and bioadhesive properties, is assessed with regard to the stability and immune fu..
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Awarded by University of Melbourne
Funding Acknowledgements
This work received financial support from the Australian National Health and Medical Research Council under the Program Grant scheme (F.C., GNT1149990) and the Innovation Project of Jinan Science and Technology Bureau (J.C., 2020GXRC022). This work was performed in part at the Materials Characterization and Fabrication Platform (MCFP) at The University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF), Peter Doherty Institute, and Ian Holmes Imaging Centre at Bio21. Figures were partly created using BioRender. The authors thank Prof. Hans Acha-Orbea (University of Lausanne) for gifting the DC1940 cell line, and Prof. Andrew Brooks (Peter Doherty Institute for Infection and Immunity) for preparation and donation of H-2Kb-SIINFEKL tetramer. The authors thank Dr. Wanjun Xu (The University of Melbourne) for the helpful discussions.